Exploring biodistribution of cannabidiol nanoparticles and nanoemulsion after intrathecal administration Background Drug delivery represents a significant challenge to effectively treating CNS disorders. Systemic administration through parenteral routes often results in low drug concentrations in the CNS. Intrathecal (IT) administration can achieve high drug concentrations in the cerebrospinal fluid. However, there are difficulties with IT drug delivery, such as inadequate drug distribution, limited drug solubility, and poor pharmacokinetic profiles, especially for lipophilic drugs, like CBD, that possess analgesic properties to treat neuropathic pain. About the study In the present study, researchers investigated how two nanocarrier formulations influence the biodistribution and nociceptive effects of CBD within the CNS after IT administration. CBD stock solutions were prepared in ethanol-propylene glycol and diluted in Intralipid nanoemulsion. Polymer-coated nanoparticle...
